Advancements in the development of subunit influenza vaccines
Identifieur interne : 000753 ( Main/Exploration ); précédent : 000752; suivant : 000754Advancements in the development of subunit influenza vaccines
Auteurs : Naru Zhang [États-Unis] ; Bo-Jian Zheng [Hong Kong] ; Lu Lu [République populaire de Chine] ; Yusen Zhou [République populaire de Chine] ; Shibo Jiang [États-Unis, République populaire de Chine] ; Lanying Du [États-Unis]Source :
- Microbes and infection / Institut Pasteur [ 1286-4579 ] ; 2014.
Abstract
The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.
Url:
DOI: 10.1016/j.micinf.2014.12.006
PubMed: 25529753
PubMed Central: 4336774
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.</p>
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